Unicorn blood

"...it is a monstrous thing, to slay a unicorn. Only one who has nothing to lose, and everything to gain, would commit such a crime. The blood of a unicorn will keep you alive, even if you are an inch from death, but at a terrible price. You have slain something pure and defenceless to save yourself, and you will have but a half-life, a cursed life, from the moment the blood touches your lips."

- Firenze explains to Harry Potter why the slaying of a unicorn is a crime.

Unicorn blood is a thick, silvery substance that runs within a Unicorn's veins. The blood of a unicorn can be drunk in order to keep a person alive. However, the act of slaying an unicorn will cause the drinker to suffer a cursed life. It is probably a Non-Tradeable Item, since the sale of this substance is controlled by the Ministry of Magic, and its trade is strictly forbidden.

1992
In 1992, Lord Voldemort used unicorn blood to sustain his life until he could steal the Philosopher's Stone to regain his true body. As he was possessing Quirinus Quirrell at the time, Quirrell drank the blood on Voldemort's behalf. Harry Potter along with the centaur Firenze saw a unicorn slautered by Quirinis Quirrel when they had to go to the Forbidden Forest for his detention.

1994
In 1994, Peter Pettigrew used unicorn blood along with Nagini's venom to concoct a potion to create a temporary body for Voldemort, until he could regain his true body. It is unknown if producing such a potion and proceeding to use it (orally or otherwise) creates a similar curse upon the user's life. In Voldemort's case, his re-usage of unicorn blood (having indirectly consumed some two years prior) may have a cumulative effect on the curse's potency.

Behind the scenes

 * As Quirrell had been drinking the unicorn blood on Voldemort's behalf, it is uncertain if he or Voldemort would have been the one afflicted with the "cursed life" mentioned by Firenze, if not both of them. It is also possible this curse may have played a part in Quirrell's death after his abandonment by Voldemort at the end of the school year.
 * It is unknown if or how Voldemort was affected by his use of unicorn blood through Quirrell in the 1991–1992 school year and again in his Rudimentary Body Potion in 1994. It is even possible it may have played some part in leading to his eventual downfall in 1998.

Appearances

 * Harry Potter and the Philosopher's Stone
 * Harry Potter and the Philosopher's Stone (film)
 * Harry Potter and the Philosopher's Stone (video game)
 * Harry Potter and the Goblet of Fire