The Mandrake Restorative Draught was particularly useful at Hogwarts School of Witchcraft and Wizardry during the events surrounding the re-opening of the Chamber of Secrets in the 1992–1993 school year. The Basilisk was released from the Chamber of Secrets and attacked numerous members of the Hogwarts community by petrifying them, including Colin Creevey, Justin Finch-Fletchley, Hermione Granger, Mrs Norris, Penelope Clearwater and Nearly-Headless Nick.
These individuals suffered complete and total paralysis, almost mirroring death, and were restored to their normal state of being when Madam Pomfrey gave them this potion. This particular potion was brewed by Severus Snape using Mandrake plants raised by Professor Sprout and the second year students at Hogwarts at that time. Gilderoy Lockhart had volunteered to make the potion, stating that he must have done it a hundred times and could do it in his sleep. Snape, however, shot him down, commenting "Excuse me, but I believe I am the Potions Master at this school."
- Harry Potter and the Chamber of Secrets (First mentioned)
- Harry Potter and the Chamber of Secrets (film) (Mentioned only)
- Harry Potter and the Chamber of Secrets (video game) (Mentioned only)
- Harry Potter: The Creature Vault (Mentioned only)