During his early career in comedy, he teamed with comic Hugh Laurie, who is currently most famous for his role as Gregory House on the FOX drama "House". He also made occasional appearances on the British version of the improvisation show "Whose Line Is It Anyway?" and is the host for the comedy quiz show QI, which recently featured Daniel Radcliffe as a panelist on a magic-themed episode, culminating in Radcliffe seemingly being beheaded by TV presenter Graham Norton.
Stephen Fry will play Malvolio in an all-male production of Twelfth Night, opposite Mark Rylance as Olivia. After opening at Shakespeare's Globe in September 2012, it will transfer to London's West End for a limited run.